The University of Arizona
http://www.genome.arizona.edu
The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome - 2004 - News
2004 : The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome
Posted by webmaster on 2004/4/8 23:00:00 ( 350 reads )

Dietrich FS, Voegeli S, Brachat S, Lerch A, Gates K, Steiner S, Mohr C, Pöhlmann R, Luedi P, Choi S, Wing RA, Flavier A, Gaffney TD, Philippsen P.

Science. 2004 Apr 9;304(5668):304-7. Epub 2004 Mar 4.

Biozentrum der Universität Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.

Abstract
We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.

Printer Friendly Page Send this Story to a Friend Create a PDF from the article
Attached Files: 304.full.pdf
Sponsors: A portion of AGIs material is based upon work supported by the National Science Foundation under Grant Number 102620